【Bachemウェビナー 3月23日1時30分~】"Solubility-directed Development of Trileucine Process"
【開催日時】 2022年３月23日（火） 1:30～2:30（60分間）※夜の時間帯となります
The excipient Trileucine is applied for improving aerosol performance and stability of spray-dried powders for inhalation. At Bachem an LPPS manufacturing process for Trileucine has already been established yielding high quality material. To allow the application of Trileucine also for aqueous solutions at neutral pH, further development work was performed to enhance the water solubility of the isolated peptide. This was successfully achieved by spray drying, but in a more straightforward way the Trileucine form with higher solubility in water could also be directly obtained by an improved crystallization process based on the results of a polymorph screening study. To learn more about this development approach as well as about Trileucine properties, manufacturing, and application in general, please join our webinar on the solubility-directed development of the Trileucine manufacturing process.
Wolfgang Seufert, Ph.D., Director of Production at Bachem
Dr. Wolfgang Seufert is a Director of Production at Bachem Bubendorf facility. At Bachem he is leading a team focusing on the scale-up development of manufacturing processes for peptides in solution. Having joined Bachem more than 13 years ago and working in several positions at the Bubendorf and Torrance facilities of Bachem, he has gained broad experience in development, scale up, and manufacturing of peptides, both LPPS and SPPS. Wolfgang Seufert studied chemistry in Germany at the universities of Giessen and Leipzig. After earning his PhD from the University of Basel (Switzerland) for his work on cyclization reactions of modified amino acids and peptides, he worked as a post-doctoral fellow at the Life Sciences Institute of the University of Michigan (USA).
<モデレーター> Laura Milbrandt, Ph.D., Business Development Manager at Bachem Americas
Laura Milbrandt is a Business Development Manager at Bachem. She is located in Boulder, Colorado and is the primary contact for our partners in the Western United States region in the area of GMP peptide API manufacture and development. In her role, she supports our customers through all phases of their project - from preclinical research and IND enabling toxicology studies to process validation and commercialization. Laura has been with Bachem for 2.5 years, and prior to this she held positions in Business Development and Project Management for API development. She earned master’s degrees in Biotechnology and Business from California State University Channel Islands.