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オリゴヌクレオチドやペプチド、それらのコンジュゲートのカスタム合成や製造サービスを提供しています。
オリゴヌクレオチドの探索研究支援
• ASO with all chiral phosphorothioates
• RNA with 3’/5’-GalNAc
• Custom 3’/5’and internal GalNAc conjugation
• PEGylation (～40 kD), etc.
オリゴヌクレオチドのAPI製造支援
• Completed 100 batches of 900mmol DNA production (>400kg delivery in total) including PPQ enabling studies and PPQ campaign in 9 months.
• Completed 3 x1.6mol ASO production in 2 months
• 20+ ongoing siRNA projects with modifications at 5’-end or 3’-end such as GalNAc and cholesterol modifications, including 11 integrated API/DP projects.
ペプチドの探索研究支援
ーハイスループット合成ー
• mg to kg scale
• High quality – Over 98% Success rate
• High purity – Up to 99.9% Purity
• Fast delivery – 2 weeks turnaround time for most peptides
• under 30 AA at mg scale
ーカスタム合成ー
• Up to 200 AA modified peptide with ligation
• Up to 70 AA modified peptide with SPPS only
• Modification: Dye/Biotin, PEG, Isotope labelling
• Peptidomimetics, Peptoid, PNA
• Cyclic peptides: Thioether, Disulfide, Biocyclic, Lactam
• RCM, Lactone, Click
ペプチドのAPI製造支援
• Long linear peptides
• Cyclic/Bicyclic peptides
• Modified peptides
• PEGylated peptides
• Peptidomimetics
• Branched peptides
